2. However, with an ever-growing understanding of cancer biology, new targeted-based or mechanism-based therapies are making there way into the clinic. MEK stands for Mitogen-Activated Protein Kinase (also Methyl Ethyl Ketone and 106 more) What is the abbreviation for Mitogen-Activated Protein Kinase? 1 The signal through the ERK pathway emanates from an activated, trans-phosphorylated cell surface receptor tyrosine kinase, which, through recruitment of … Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2. Additionally, the Raf-MEK-ERK pathway is a key downstream effector of the Ras small GTPase, the most frequently mutated oncogene in human cancers. If the compound efficiently inhibits the target but has no clinical response, then it allows researchers to conclude that the target is not important for that particular cancer. This arrangement channels the unique input signals that activate the pathway into the specific output signaling in distinct spatio-temporal patterns. Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. The list of acronyms and abbreviations related to MEK - MAP kinase kinase In the mammalian MAP kinase pathway, analogous functions may be distributed among several proteins, acting at different steps in the pathway, with MP1 facilitating the functional interactions involving MEK. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAThe important issues that MAPK drug discovery faces are those that have accompanied the new era of target-based anticancer drug discovery. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). MEK1 and MEK2 are closely related, dual-specificity tyrosine/threonine protein kinases found in the Ras/Raf/MEK/ERK mitogen- activated protein kinase (MAPK) signaling pathway. This review will highlight the recent progress in this area. We apologize to all colleagues whose work could not be cited due to space limitations. Thus, the EGFR-Ras-Raf-MEK-ERK signaling network has been the subject of intense research and pharmaceutical scrutiny to identify novel target-based approaches for cancer treatment. In particular, scaffold proteins (e.g., KSR, Sef, MP1 and IQGAP1) bind to distinct subsets of components of this cascade to create unique ERK MAPK signaling complexes at specific and distinct subcellular locations that result in preferential utilization of only some of the many possible ERK substrates. Historically, oncology drug development has focused on determining the maximum tolerated dose (MTD), safety profile and efficacy of a compound whereas mechanistic studies and efforts to preselect responders were almost never undertaken. The list of abbreviations related to MEK - Mitogen-Activated Protein Kinase. Although these novel agents offer great promise for significant improvements in cancer chemotherapy, they have also brought researchers and clinicians several new challenges and issues for drug discovery. The existence of multiple small proteins that serve adapter functions would provide enhanced flexibility in regulating the efficiency and specificity of the MAP kinase cascade. Aberrant regulation of MAPK cascades contribute to cancer and other human diseases. These compounds differ greatly from the majority of the conventional cytotoxic antineoplastic drugs in that they are rationally designed to mechanistically inhibit a particular protein target that is hypothesized to be critical for cancer growth and progression.

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